Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol
November 29, 2018
This paper outlines the study protocol for a stepped wedge cluster randomised controlled trial to test the effectiveness of topical insect repellent delivered by village health volunteers in isolated villages in South East Myanmar.
Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia
November 15, 2018
Red blood cells destruction through loss of complement regulatory proteins (CRPs) is an immunopathogenic mechanism that contributes to malaria anaemia in Plasmodium falciparum. However, its role in P. vivax malaria is unknown. Our study showed CR1 and CD55 were reduced in severe anaemia in both falciparum and vivax malaria. The loss of CRPs however, was only restricted to uninfected RBCs, with infected RBCs having higher expressions. This study highlights the likely critical role of reduced CRPs expression on uninfected RBCs in falciparum and vivax malaria anaemia, and demonstrated that higher CRPs expression on infected RBCs may suggest parasite’s invasion and immune evasion strategy.