Professor James McCarthy is a Senior Scientist at QIMR Berghofer Medical Research Institute, and an Infectious Diseases Physician at Royal Brisbane and Womens Hospital, both in Brisbane, Australia. His clinical and research training were undertaken in Australia, the United Kingdom, at the University of Maryland and the Laboratory for Parasitic Diseases, National Institutes of Health, Bethesda, MD, before returning to Australia in 1997. A major focus of his research is the development and application of clinical trial systems that entail deliberate infection of human volunteers with malaria parasites by intravenous injection of Plasmodium-infected red blood cells. Volunteers are then studied in the pre-symptomatic period by qPCR to evaluate investigational drugs, vaccines and diagnostics for malaria.Related Projects
- An external quality assurance program for PCR assays to quantify parasitaemia across laboratories in the Asia-Pacific region
- Developing better tools for diagnosing patients and populations at risk of primaquine induced haemolysis
- Developing new diagnostic tests for malaria
- Evaluation and prediction of the effect of combinations of antimalarial drugs
- Identifying better treatments for uncomplicated malaria
- Understanding kinetics of antigens used in rapid diagnostic tests for malaria
- Within-host malaria modelling to improve the treatment of malaria
Related Publications
- A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early P. falciparum in an induced blood-stage malaria infection study
- Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against clinical malaria
- Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection
- Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
- Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance
- Plasmodium malariae and ovale genomes provide insights into malaria parasite evolution
- Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium Vivax Volunteer Infection Study
- Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
- Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study
- Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency
- Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent Plasmodium falciparum infection
- Within-host modeling of blood-stage malaria