Malaria elimination results in heterogeneous pockets of transmission that need to be identified and then targeted with specific interventions that are locally appropriate to interrupt that transmission. Although there are several models that can be adopted (for example, mass drug administration, mass screen and treat), all these approaches benefit from high precision GIS mapping to clearly delineate symptomatic cases and identify asymptomatically infected individuals, and the areas where they are infected. A range of GIS and digital data collection strategies are being used by ACREME researchers to enable real-time data acquisition and precise geospatial localisation. This data is then used to plan and respond with appropriate interventions, which are also precisely mapped. These interventions can then be monitored closely to ascertain their effectiveness and to determine when interventions need to be intensified and repeated.