Publications

Mayeta Clark 2015

Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium Vivax Volunteer Infection Study

May 16, 2020

Chloroquine has been used for the treatment of malaria for more than 70 years; however, chloroquine pharmacokinetic (PK) and pharmacodynamic…

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Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis

May 14, 2020

Background The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce…

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Cost-Effectiveness Analysis of Sex-Stratified Plasmodium vivax Treatment Strategies Using Available G6PD Diagnostics to Accelerate Access to Radical Cure

May 4, 2020

Tafenoquine has been licensed for the single-dose radical cure of Plasmodium vivax in adults; however, it is only recommended in patients with…

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Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial

March 31, 2020

This study evaluated functional antibody responses in clinical trials of RTS,S and demonstrated for the first time that vaccination with RTS,S induces antibodies that function to recruit complement and activate specialised immune cells against malaria.

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The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study

February 20, 2020

Background An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a…

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Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study

January 29, 2020

Background: In endemic regions, the age distribution of malaria varies according to the infecting Plasmodium species. We aimed to delineate the…

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Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

January 16, 2020

Background In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells…

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Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

November 27, 2019

Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to…

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Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

November 13, 2019

Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to identifying targets of immunity to malaria. Here, we used…

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