Publications

Mayeta Clark 2015

Multiple morbidities in pregnancy: Time for research, innovation, and action

September 25, 2018

Multimorbidity is a major issue affecting pregnant women globally. Infectious diseases (such as HIV, malaria, tuberculosis, and sexually transmitted infections [STIs]) together with NCDs that are increasingly common in LMICs as a result of demographic, socioeconomic, and environmental changes (cardiovascular disease, diabetes, anemia, micronutrient deficiencies, hypertension, and mental health challenges) each account for substantial morbidity in pregnancy. However, the burden of their combination is less well recognized, and the impacts are not well understood. In most malaria endemic populations, the burden of multimorbidities is very high such that malaria typically co-occurs with numerous other health problems and health risks. In this editorial, the authors call for greater investment in research, innovation, and translation to drive the development of new tools, interventions, and strategies, including greater investment in this are by the industry sector. They identify main priorities for research and innovation across levels of healthcare, and the need for workforce development and health system–patient–community partnerships for care and interventions across the spectrum of reproductive, maternal, and child health.

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In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance

September 24, 2018

Antimalarial treatment currently relies on an artemisinin derivative and a longer acting partner drug. With the emergence of resistance to…

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Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study

September 20, 2018

Anemia and iron deficiency are common in malaria-endemic regions, but there are concerns regarding the value of iron supplementation among pregnant women in malaria-endemic areas due to reports that iron supplementation may increase the risk of malaria. There is a lack of evidence on the impact of iron deficiency on pregnancy outcomes in malaria-endemic regions
In a cohort of pregnant women in Papua New Guinea, it was found that iron deficiency was highly prevalent and associated with substantially reduced odds of low birth weight. This affect appeared to be only partly through malaria-protective mechanisms, and other protective mechanisms may be involved. The findings suggest that suggest that iron supplementation needs to be integrated with other strategies to prevent or treat infections and undernutrition in pregnancy to achieve substantial improvements in birth outcomes.

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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

September 18, 2018

Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is…

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Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling

August 27, 2018

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative co-administered…

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Within-host modeling of blood-stage malaria

August 11, 2018

Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmodium…

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Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model.

August 2, 2018

Background Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet…

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The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis

July 19, 2018

Background Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria despite increasing reports of treatment failure. We did a systematic review…

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Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens

May 23, 2018

Describes a novel algorithm for measuring relatedness between malaria parasites and other recombining pathogens, and to identify specific genes under selection. The research paves the way for defining transmission networks and to track the origins and spread of drug resistance.

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Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

April 30, 2018

Background Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize…

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