Publications

Mayeta Clark 2015

Genomic epidemiology of artemisinin resistant malaria

March 4, 2016

This study investigated the global prevalence and spread of Kelch13 mutants responsible for artemisinin resistance. The study found that whilst mutants were abundant in South East Asia, there was a very low prevalence in other parts of the world, and importantly, that resistant parasites have not yet spread to Africa.

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Structure- and function-based design of Plasmodium-selective proteasome inhibitors

February 11, 2016

The team used a revolutionary technique called Cryo-Electron Microscopy to determine the 3D structure of the malaria parasite proteasome. This enabled design of an inhibitor that is able to attenuate parasite growth in vivo without significant toxicity to the host. The compound is active against strains of the malaria parasite from South East Asia that are resistant to currently used antimalarial drugs.

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Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

February 11, 2016

MSP2 is an intrinsically disordered protein that is abundant on the merozoite surface and essential to the parasite Plasmodium falciparum….

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Acquisition and longevity of antibodies to Plasmodium vivax pre-erythrocytic antigens in Western Thailand

February 1, 2016

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Falling Plasmodium knowlesi malaria death rate among adults despite rising incidence, Sabah, Malaysia, 2010-2014

January 1, 2016

Deaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. We…

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Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model

October 27, 2015

This world-first study identified that a very high proportion (80%) of P. vivax infections arise from dormant hypnozoites and sustain transmission. This study provided key evidence presented at 2017 WHO Expert Review Group Meeting demonstrating that currently available malaria control interventions will be insufficient to achieve elimination of P. vivax, highlighting the need to develop novel diagnostics and surveillance strategies.

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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model

October 27, 2015

Using an innovative design, this study proved that 80% of all P. vivax bloodstage infections are caused by relapses from long-lasting liverstages and using mathematical models we predicted that elimination of P. vivax will be difficult without attacking the silent hypnozoite reservoir.

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Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

October 1, 2015

Monoclonal antibodies are being developed as therapeutics to complement drugs and vaccines or to fill the gap where no drugs…

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Treatment policy change to dihydroartemisinin-piperaquine contributes to the reduction of adverse maternal and pregnancy outcomes

July 15, 2015

Background In Papua, Indonesia, maternal malaria is prevalent, multidrug resistant and associated with adverse outcomes for mother and baby. In…

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Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea

May 21, 2015

We used state-of-the-art molecular assays to generate evidence on who is most likely to be infected with gametocytes and thereby contributing most to sustained transmission. This method has been adopted as the preferred means of estimating gametocyte prevalence/density from asexual parasite prevalence.

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