Publications

Mayeta Clark 2015

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

October 1, 2015

Monoclonal antibodies are being developed as therapeutics to complement drugs and vaccines or to fill the gap where no drugs…

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Treatment policy change to dihydroartemisinin-piperaquine contributes to the reduction of adverse maternal and pregnancy outcomes

July 15, 2015

Background In Papua, Indonesia, maternal malaria is prevalent, multidrug resistant and associated with adverse outcomes for mother and baby. In…

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Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea

May 21, 2015

We used state-of-the-art molecular assays to generate evidence on who is most likely to be infected with gametocytes and thereby contributing most to sustained transmission. This method has been adopted as the preferred means of estimating gametocyte prevalence/density from asexual parasite prevalence.

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Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination

May 7, 2015

This is the first investigation of the molecular epidemiology of malaria across multiple sites in Indonesia, and one of the first studies to demonstrate consistently greater diversity reflective of more stable transmission in P. vivax relative to P. falciparum in a range of endemic settings. The study highlighted the need for concerted efforts to target the major reservoirs of P. vivax infection if malaria elimination is to be successful in co-endemic regions.

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Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against clinical malaria

March 17, 2015

Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier…

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The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a pooled analysis of individual patient data

March 15, 2015

The paper highlights underdosing of lumefantrine in young children and has also been incorporated into the latest WHO Antimalarial Therapeutic Guidelines.

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Ultra-Sensitive Detection of Plasmodium falciparumby Amplification of Multi-Copy Subtelomeric Targets

March 3, 2015

This manuscript describes the development of a novel PCR method for detecting ultra low-density P. falciparum infections previously not detectable by any other method but contributing to ongoing transmission.

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Sulphadoxine-pyrimethamine plus azithromycin for the prevention of low birthweight in Papua New Guinea: a randomised controlled trial

January 16, 2015

A large trial in nearly 2800 women showed a combination of sulphadoxine and pyrimethamine with azithromycin to decrease low birth weight and preterm birth in Papua New Guinea.

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Parasite Biomass-Related Inflammation, Endothelial Activation, Microvascular Dysfunction and Disease Severity in Vivax Malaria

January 8, 2015

Plasmodium vivax can cause severe malaria, however its pathogenesis is poorly understood. In contrast to P. falciparum, circulating vivax parasitemia is low,…

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Modelling the contribution of the hypnozoite reservoir to Plasmodium vivax transmission

November 18, 2014

This manuscript outlines the first mathematical model that explicitly models the contribution of relapsing infections to P. vivax transmission. This model has since served as the basis of more advanced models investigating both the effect of different intervention on P. vivax transmission and evolutionary advantages of different relapse phenotypes.

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