Mayeta Clark 2015

Low antibody levels to pregnancy-specific malaria antigens and heightened cytokine responses associated with severe malaria in pregnancy

November 25, 2013

Sudanese pregnant women with severe malaria had low levels of pregnancy-specific antibody suggesting low immunity, and had high blood cytokine levels. Lack of immunity may predispose to severe pregnancy malaria.

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Further shrinking the malaria map: How can geospatial science help achieve malaria elimination?

August 1, 2013

This paper outlines spatial decision support tools that have been adopted by control programs.

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Identification and prioritization of merozoite antigens as targets of protective human immunity to falciparum malaria for vaccine and biomarker development

June 17, 2013

The first comprehensive evaluation of merozoite antigens as targets of human immunity, including 96 antigens, which examined responses in detail in a longitudinal cohort of over 200 children. The study identified several antigens as strong targets of protective immunity that underpins a rational approach to vaccine development and biomarker development.

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Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

March 26, 2013

Antimalarial resistance is poorly understood, yet potentially devastating. We introduced a cutting edge experimental procedure and mathematical framework to probe the development of drug resistance.

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Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children

June 4, 2012

This study established a new molecular-epidemiological metric of malaria transmission, the molecular force of infections, and demonstrated that it is the key determinant of the risk of P. falciparum infections and disease in young PNG children.

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Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial

March 27, 2012

This large, randomised placebo-controlled trial was the first to demonstrate the efficacy of IPTi for the prevention of malaria in children outside Africa and equally the first to prove its efficacy against P. vivax malaria.

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Modelling the dynamics of Plasmodium falciparum histidine-rich protein 2 in human malaria to better understand malaria rapid diagnostic test performance

March 19, 2012

Background Effective diagnosis of malaria is a major component of case management. Rapid diagnostic tests (RDTs) based on┬áPlasmodium falciparumhistidine-rich protein…

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Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission

September 9, 2011

Background The epidemiology of congenital malaria was investigated in a hospital-based malaria surveillance study in Papua, Indonesia. Methods From April…

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The relationship between anti-merozoite antibodies and incidence of P. falciparum malaria: A systematic review and meta-analysis.

January 19, 2010

A novel systematic review and meta-analysis that provided crucial new evidence supporting merozoite antigens as targets of human immunity and vaccine candidates.

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