Publications

Mayeta Clark 2015

Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial

March 31, 2020

This study evaluated functional antibody responses in clinical trials of RTS,S and demonstrated for the first time that vaccination with RTS,S induces antibodies that function to recruit complement and activate specialised immune cells against malaria.

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The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study

February 20, 2020

Background An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a…

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Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study

January 29, 2020

Background: In endemic regions, the age distribution of malaria varies according to the infecting Plasmodium species. We aimed to delineate the…

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Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

January 16, 2020

Background In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells…

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Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting

November 27, 2019

Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to…

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Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants

November 13, 2019

Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to identifying targets of immunity to malaria. Here, we used…

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Early and late mortality after malaria in young children in Papua, Indonesia

October 30, 2019

Background In southern Papua, Indonesia, malaria is highly prevalent in young children and is a significant cause of morbidity and…

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Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

October 29, 2019

Renewed efforts to eliminate malaria have highlighted the potential to interrupt human-to-mosquito transmission — a process mediated by gametocyte kinetics…

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The efficacy of dihydroartemisininpiperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis

October 4, 2019

Background Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook…

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