Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling
August 27, 2018
The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative co-administered…
Within-host modeling of blood-stage malaria
August 11, 2018
Malaria infection continues to be a major health problem worldwide and drug resistance in the major human parasite species, Plasmodium…
Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model.
August 2, 2018
Background Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet…
The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis
July 19, 2018
Background Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria despite increasing reports of treatment failure. We did a systematic review…
Identity-by-descent analyses for measuring population dynamics and selection in recombining pathogens
May 23, 2018
Describes a novel algorithm for measuring relatedness between malaria parasites and other recombining pathogens, and to identify specific genes under selection. The research paves the way for defining transmission networks and to track the origins and spread of drug resistance.
Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
April 30, 2018
Background Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize…
Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem
April 1, 2018
This article reviews progress over the previous 10 years in understanding the pathogenesis, burden and costs of malaria in pregnancy. It was produced by the Malaria in Pregnancy Consortium.
Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures
March 12, 2018
Humoral immune responses against the malaria parasite are an important component of a protective immune response. Antibodies are often directed…
Age-related clinical spectrum of Plasmodium knowlesi malaria and predictors of severity
March 5, 2018
Background Plasmodium knowlesi is increasingly reported in Southeast Asia, but prospective studies of its clinical spectrum in children and comparison with…
Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific
January 26, 2018
This paper describes the changing patterns of malaria parasite (Plasmodium vivax) population genetic structure with declining transmission across the Southwest Pacific. The work has identified specific parameters that can be measured to track elimination progress.