Falling Plasmodium knowlesi malaria death rate among adults despite rising incidence, Sabah, Malaysia, 2010-2014
January 1, 2016
Deaths from Plasmodium knowlesi malaria have been linked to delayed parenteral treatment. In Malaysia, early intravenous artesunate is now recommended for all severe malaria cases. We…
Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model
October 27, 2015
This world-first study identified that a very high proportion (80%) of P. vivax infections arise from dormant hypnozoites and sustain transmission. This study provided key evidence presented at 2017 WHO Expert Review Group Meeting demonstrating that currently available malaria control interventions will be insufficient to achieve elimination of P. vivax, highlighting the need to develop novel diagnostics and surveillance strategies.
Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model
October 27, 2015
Using an innovative design, this study proved that 80% of all P. vivax bloodstage infections are caused by relapses from long-lasting liverstages and using mathematical models we predicted that elimination of P. vivax will be difficult without attacking the silent hypnozoite reservoir.
Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
October 1, 2015
Monoclonal antibodies are being developed as therapeutics to complement drugs and vaccines or to fill the gap where no drugs…
Treatment policy change to dihydroartemisinin-piperaquine contributes to the reduction of adverse maternal and pregnancy outcomes
July 15, 2015
Background In Papua, Indonesia, maternal malaria is prevalent, multidrug resistant and associated with adverse outcomes for mother and baby. In…
Blood-Stage Parasitaemia and Age Determine Plasmodium falciparum and P. vivax Gametocytaemia in Papua New Guinea
May 21, 2015
We used state-of-the-art molecular assays to generate evidence on who is most likely to be infected with gametocytes and thereby contributing most to sustained transmission. This method has been adopted as the preferred means of estimating gametocyte prevalence/density from asexual parasite prevalence.
Contrasting Transmission Dynamics of Co-endemic Plasmodium vivax and P. falciparum: Implications for Malaria Control and Elimination
May 7, 2015
This is the first investigation of the molecular epidemiology of malaria across multiple sites in Indonesia, and one of the first studies to demonstrate consistently greater diversity reflective of more stable transmission in P. vivax relative to P. falciparum in a range of endemic settings. The study highlighted the need for concerted efforts to target the major reservoirs of P. vivax infection if malaria elimination is to be successful in co-endemic regions.
Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against clinical malaria
March 17, 2015
Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier…
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a pooled analysis of individual patient data
March 15, 2015
The paper highlights underdosing of lumefantrine in young children and has also been incorporated into the latest WHO Antimalarial Therapeutic Guidelines.
Ultra-Sensitive Detection of Plasmodium falciparumby Amplification of Multi-Copy Subtelomeric Targets
March 3, 2015
This manuscript describes the development of a novel PCR method for detecting ultra low-density P. falciparum infections previously not detectable by any other method but contributing to ongoing transmission.