Publications

Mayeta Clark 2015

An Exported Protein-Interacting Complex involved in the trafficking of virulence determinants in Plasmodium-infected erythrocytes

July 10, 2017

The particular virulence of P. falciparum is associated with binding of parasite-infected red blood cells (RBCs) to sites in the brain and the placenta. Despite its importance, the mode of trafficking and display of the parasite-encoded adhesin, PfEMP1 at the RBC surface is poorly understood. Here we define the PfEMP1 binding partners en route to the RBC membrane and show that export involves a novel protein complex, which we refer to as the Exported Protein-Interacting Complex (EPIC).

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Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

June 1, 2017

This recent publication describes the work James McCarthy led to first test the safety of a New Chemical Entity in humans then to define its antimalarial activity in the human challenge system he developed.

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Comparison of artemether-lumefantrine and chloroquine with and without primaquine for the treatment of Plasmodium vivax in Ethiopia: a randomized controlled trial

May 16, 2017

Important trial highlighting benefits of adding primaquine to ACT for radical cure of P. vivax which lead to a change in treatment policy in Ethiopia.

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Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions

May 11, 2017

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Asymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailand

April 28, 2017

Background Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within…

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Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

April 22, 2017

Resistance to the main antimalarial drug artemisinin is emerging. This work shows that the parasite protects itself against artemisinins by activating a cellular stress response. We showed that extending the course of treatment with artemisinins or combining them with clinically-used anti-cancer drugs can overcome artemisinin resistance.

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Initiation of gametocytogenesis at very low parasite density in Plasmodium falciparum infection

April 1, 2017

It has long been speculated where the malaria parasite changes from the blood stage asexual form to the gametocyte that is ready for mosquito infection. Using a novel approach and material from the human challenge study, this study demonstrated that the parasite commits to its sexual stage while in the circulation.

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An open access platform for comparative analysis of short tandem repeat genotyping data in Plasmodium vivax populations

March 31, 2017

This paper presents an online tool (vivaxGEN) and standardized methodology to compare parasite populations across multiple endemic settings. VivaxGEN originated within the vivax Working Group of the Asia Pacific Malaria Elimination Network (APMEN) as a platform to facilitate data sharing between countries for a regional overview of parasite transmission within and across borders.

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Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort

March 28, 2017

This multinational study demonstrated that in populations with high levels of immunity and faster parasite clearance, early signs of low-grade resistance went undetected, and conversely, in populations with lower immunity and slower parasite clearance, a false impression of reduced antimalarial efficacy resulted.

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A comparison of three methods to estimate G6PD activity in the Chittagong Hill Tracts, Bangladesh

January 25, 2017

Background Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based…

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