Mayeta Clark 2015

Malaria elimination in India and regional implications

August 12, 2016

This paper outlines challenges and potential solutions posed by malaria in India to regional elimination goals.

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Asymptomatic Vivax and Falciparum Parasitaemia with Helminth Co-Infection: Major Risk Factors for Anaemia in Early Life

August 9, 2016

Background Anaemia in children under five years old is associated with poor health, growth and developmental outcomes. In Papua, Indonesia,…

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Genomic Analysis Reveals a Common Breakpoint in Amplifications of the Plasmodium vivax Multidrug Resistance 1 Locus in Thailand

July 24, 2016

This study describes the use of genomic data to develop a simple and high-throughput new molecular surveillance assay to detect drug resistance-conferring gene copy number amplifications in polyclonal P. vivax infections.

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Genomic analysis of local variation and recent evolution in Plasmodium vivax

June 27, 2016

This landmark study of the genomic epidemiology of multiple P. vivax populations from across the Asia-Pacific region revealed new insights into parasite transmission and identified novel drug resistance candidates for this species.

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Efficacy of artesunate-mefloquine for chloroquine-resistant Plasmodium vivax malaria in Malaysia: an open-label randomised controlled trial

June 1, 2016

Background Chloroquine (CQ)-resistant Plasmodium vivax is increasingly reported throughout southeast Asia. The efficacy of CQ and alternative artemisinin combination therapies (ACTs) for…

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Malaria burden and costs of intensified control in Bhutan, 2006–14: an observational study and situation analysis.

May 1, 2016

This original research quantifies the malaria burden and programmatic costs of malaria elimination in Bhutan.

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Reversible host cell remodelling underpins deformability changes in malaria parasite sexual blood stages

April 26, 2016

The sexual stages of P. falciparum adopt a unique crescent shape. We showed that a network of microtubules lies under the parasite surface and drives parasite elongation. We showed that shape and deformability changes facilitate survival in the circulation so the sexual stage parasites can be picked up by a mosquito and transmitted to the next victim.

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Genomic epidemiology of artemisinin resistant malaria

March 4, 2016

This study investigated the global prevalence and spread of Kelch13 mutants responsible for artemisinin resistance. The study found that whilst mutants were abundant in South East Asia, there was a very low prevalence in other parts of the world, and importantly, that resistant parasites have not yet spread to Africa.

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Structure- and function-based design of Plasmodium-selective proteasome inhibitors

February 11, 2016

The team used a revolutionary technique called Cryo-Electron Microscopy to determine the 3D structure of the malaria parasite proteasome. This enabled design of an inhibitor that is able to attenuate parasite growth in vivo without significant toxicity to the host. The compound is active against strains of the malaria parasite from South East Asia that are resistant to currently used antimalarial drugs.

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Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

February 11, 2016

MSP2 is an intrinsically disordered protein that is abundant on the merozoite surface and essential to the parasite Plasmodium falciparum….

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