January 25, 2017
Background Glucose-6-phosphate-dehydrogenase-deficiency (G6PDd) is a major risk factor for primaquine-induced haemolysis. There is a need for improved point-of-care and laboratory-based…
Differential effect of mass deworming and targeted deworming for soil-transmitted helminth control in children: a systematic review and meta-analysis
December 13, 2016
This systematic review and meta-analysis quantifies the impact of deworming whole communities on child infections with tropical parasitic worm infections.
Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission
December 8, 2016
Clinical experimental systems to investigate P. vivax infection, and specifically transmission to mosquito have been lacking. In this paper we describe the development of a novel approach to undertaking clinical trials in P. vivax to test transmission-blocking interventions.
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early P. falciparum in an induced blood-stage malaria infection study
September 13, 2016
This human challenge study provided key data for the advancement of Ferroquine into a pivotal Phase II study that is currently underway in Africa.
August 12, 2016
This paper outlines challenges and potential solutions posed by malaria in India to regional elimination goals.
Asymptomatic Vivax and Falciparum Parasitaemia with Helminth Co-Infection: Major Risk Factors for Anaemia in Early Life
August 9, 2016
Background Anaemia in children under five years old is associated with poor health, growth and developmental outcomes. In Papua, Indonesia,…
Genomic Analysis Reveals a Common Breakpoint in Amplifications of the Plasmodium vivax Multidrug Resistance 1 Locus in Thailand
July 24, 2016
This study describes the use of genomic data to develop a simple and high-throughput new molecular surveillance assay to detect drug resistance-conferring gene copy number amplifications in polyclonal P. vivax infections.
June 27, 2016
This landmark study of the genomic epidemiology of multiple P. vivax populations from across the Asia-Pacific region revealed new insights into parasite transmission and identified novel drug resistance candidates for this species.
Efficacy of artesunate-mefloquine for chloroquine-resistant Plasmodium vivax malaria in Malaysia: an open-label randomised controlled trial
June 1, 2016
Background Chloroquine (CQ)-resistant Plasmodium vivax is increasingly reported throughout southeast Asia. The efficacy of CQ and alternative artemisinin combination therapies (ACTs) for…
Malaria burden and costs of intensified control in Bhutan, 2006–14: an observational study and situation analysis.
May 1, 2016
This original research quantifies the malaria burden and programmatic costs of malaria elimination in Bhutan.